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Challenges of Cholangiocarcinoma Detection in Patients with Primary Sclerosing Cholangitis

Authors

  • James H. Tabibian

    Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA

  • Keith D. Lindor

    Executive Vice Provost, Health Solutions, Arizona State University, P.O. Box 877805, Tempe, AZ 85287-7805, USA

DOI:

https://doi.org/10.6000/1927-7229.2012.01.01.7

Keywords:

Neoplasm, bile duct neoplasms, bile duct diseases, biological tumor marker, magnetic resonance imaging, ultrasonography, cytological techniques, fluorescence in situ hybridization, early detection of cancer, mass screening, imaging, cholangiography

Abstract

 Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibro-obliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma (CCA). The development of CCA in PSC is unpredictable, its surveillance and diagnosis complex, and its treatment options limited unless detected early. Herein we provide a focused review of the current literature regarding CCA surveillance in patients with PSC and discuss the diagnostic and management challenges that exist. Where evidence is limited, we present our perspective and approach as well as directions for future research.

References

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Published

2012-01-28

Issue

Vol. 1 No. 1 (2012)

Section

Articles

How to Cite

Challenges of Cholangiocarcinoma Detection in Patients with Primary Sclerosing Cholangitis . (2012). Journal of Analytical Oncology, 1(1), 50-55. https://doi.org/10.6000/1927-7229.2012.01.01.7

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