Logo

Prevalence of Precancerous Lesions among Positive HIV Women in the Hospital Complex and University of Yaounde (Cameroun)

Authors

  • Dominique Vanessa Sob Djuendje

    Department of Biomedical and Health Care Sciences, Faculty of Biomedical Sciences, Cameroon Evangelical University Institute, P.O Box: 127 Bandjoun, Cameroon

  • Armel Herve Nwabo Kamdje

    Department of Biomedical Sciences, Faculty of Sciences, University of Ngaoundere, Ngaoundere, Cameroun

  • Blaise Nkegoum

    Anatomo Pathology Service, Central and General Hospital of Yaounde, P. O Box 2787, Yaounde, Cameroon

DOI:

https://doi.org/10.6000/1927-7229.2017.06.02.3

Keywords:

Precancerous lesions, AIDS, Prevalence.

Abstract

 In the year 2000, a wide campaign of screening and treatment of the dysplastic lesions of the cervix was initiated in Cameroun. The precancerous lesions of the cervix are the most important demonstration of gynecological infection by the AIDS. As these lesions remain little documented in Cameroun, we carried out a study which the goal was to determine the prevalence of the precancerous lesions among positive AIDS women.

It is about a descriptive study with a retrospective collection of data carried out between 2010 and 2016 among 253 positive AIDS women having carried out a consultation in the Hospital complex and University of Yaounde aged from 18 to 80 years. The analysis of the data was essentially carried on: the age, clinical Factors data of risk of the precancerous lesions, anatomo-pathological search of precancerous lesion. AIDS status and/or the catch the antiretroviral one. The Software SPSS was used for the analysis of data. The test of Chi2 for the comparison of the variables. A variable was considered significant if P<0,05.

53 women presented precancerous lesions i.e. 20,94%. The lesions were in 92% of the squamous lesions with intra epithelial of low rank and in 8% of the squamous lesions with intra epithelial of high rank. 22 women (38%) were aged between 36 and 45 years; 22 women (40%) were housewives; 18 women (31%) were single people; 36 women (67%) were multipares; 45 women (85%) did not smoke; 33 women (62%) had a peak of CD4 located between 500-1000/mm3;14 women (26%) did not have opportunist diseases 10 women (19%) had the zona, 8 women (15%) of tuberculosis and 9 women (17%) suffered from HTA.

Because of the high potential risk of precancerous lesions in our population of study, we recommend a regular clinical follow-up of the patients presenting high factors of risk, and a widened access to antiretroviral.

References

Hussein WM, Anwar WA, Attaleb M, Mazini L, Försti A, Trimbitas RD, Khyatti M. A review of the infection-associated cancers in North African countries. Infect Agent Cancer 2016; 11: 35. https://doi.org/10.1186/s13027-016-0083-8

Pierre A. Cancers in developing countries. Tropical medicine 2013; P 01.

Yeni P. Management of people infected with HIV. Recommendation of the expert group. The French documentation Paris 2010; 417 p. ISBN 978-2-11-008038-7.

Cervical Cancer Action. Progress towards cervical cancer prevention: A review of the CCA 2012; P 6.

Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol 2016. https://doi.org/10.1001/jamaoncol.2016.5688

Sharma A, Kulkarni V, Bhaskaran U, et al. Profile of cervical cancer patients attending Tertiary Care Hospitals of Mangalore, Karnataka: A 4 year retrospective study. J Nat Sci Biol Med 2017; 8(1): 125-129. https://doi.org/10.4103/0976-9668.198354

Tebeu PM, Sandjong I, Nkele N, Foukoua S, Achu P, Kouam L, Doh AS. Precancerous lesions of the cervix in rural areas: cross-sectional study. Medicine d’Afrique noire 2005; 52(1): 28-30.

ECLAIRAGES. Health information bulletin Cameroon 2011; 3: 1.

Breslau ES, Weiss ES, Williams A, Burness A, Kepka D. The implementation road: engaging community partnerships in evidence based cancer control interventions. Health Promot Pract 2015; 16(1): 46-54. https://doi.org/10.1177/1524839914528705

High Authority of Health (HAS). Screening and prevention of cervical cancer. Update of the practice of the periodic health examination 2013; P 4.

Mesonego J. Prevention of cervical cancer: challenges and prospects for vaccination against papillomavirus. Obstetric Gynecology & Fertility 2006; 34: 189-201.

Stoler MH, Schiffman M. Interobserver reproductibility of cervical cytology interpretation realistic estimates from ASCUS-LSIL. Titration study. JAMA 2001; 285: 1500-5. https://doi.org/10.1001/jama.285.11.1500

Farahnaz K, Anisodowleh N, Taravat F, Mansour R, Ahmad K, Nasrin E, Shirin NB. Cervical visual inspection with acetic acid as an alternative screening test for cervical cancer detection. International Journal of Collaborative Research on Internal Medicine & Public Health 2013; 5(1): 60-66.

Zhou F, Zhang L, Zhao KN. Molecular Approaches Target to Immunotherapy for HPV-Associated Cancers. Curr Cancer Drug Targets 2016; 17: 9.

Suriya P, Aiyavu C, Gobinath S. screening and prevention of HPV infected cervical cancer. IJESC 2016; 6(5): 4940-4946

Nkegoum B, Belley Priso E, Mbakop A, Gwet bell E. Precancerous lesions of the cervix in Cameroonian women. Cytological and epidemiological aspects of 946 cases. Gynécol OhstétFel1il 2001; 29: 15-20.

Doh AS, Kouam L. The management of preinvasive cervical lesion using cryotherapy in Yaounde, Cameroon. J Obstet Gynecol 1999; 19(6): 640-642. https://doi.org/10.1080/01443619963932

Mpiga E, Mahine I, Koumakpayi I, Engohan-Aloghe C, Chansi Ankély J, Belembaogo E, Meye JF. Interest of visual inspection with acetic acid and lugol solute with colposcope in the detection of cervical lesions in Gabon. PanAfrican Medical Journal 2015; ISSN: 1937-8688.

Strohmeier R, Naujoks H, van Driel-Kulker AM, Ploem JS. Laboratory test of an automated cell analysis system for cervical screening. Cytopathology 1993; 4(3): 139-47. https://doi.org/10.1111/j.1365-2303.1993.tb00079.x

Zahnd WE, Jenkins WD, Mueller-Luckey GS. Cancer Mortality in the Mississippi Delta Region: Descriptive Epidemiology and Needed Future Research and Interventions. J Health Care Poor Underserved 2017; 28(1): 315-328. https://doi.org/10.1353/hpu.2017.0025

Downloads

Published

2017-12-28

Issue

Vol. 6 No. 2 (2017)

Section

Articles

How to Cite

Prevalence of Precancerous Lesions among Positive HIV Women in the Hospital Complex and University of Yaounde (Cameroun). (2017). Journal of Analytical Oncology, 6(2),  103-106. https://doi.org/10.6000/1927-7229.2017.06.02.3

Similar Articles

11-20 of 29

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)