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Treatment Experience of Pelvic Osteosarcoma Arising in Li-Fraumeni Syndrome

Authors

  • Eiji Kozawa

    Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Kenji Ina

    Palliative Care Team, Nagoya Memorial Foundation, Nagoya, 468-8520, Japan and Department of Geriatric Medicine, Shinseikai Dai-ichi Hospital, Nagoya, 468-0031, Japan

  • Yuko Kato

    Palliative Care Team, Nagoya Memorial Foundation, Nagoya, 468-8520, Japan and Medical Social Work Consultation Room, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Atsushi Morizane

    HOSPY Renal Dialysis Division, Clinical Engineering, Nagoya 468-0031, Japan

  • Megumi Kabeya

    Palliative Care Team, Nagoya Memorial Foundation, Nagoya, 468-8520, Japan and Department of Phamacy, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Tomoko Nishio

    Department of Pathology, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Koki Shimizu

    Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Akiko Fujita

    Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Naohiro Osada

    Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

  • Masatake Tsunoda

    Department of Orthopedic Surgery, Nagoya Memorial Hospital, Nagoya, 468-8520, Japan

DOI:

https://doi.org/10.30683/1927-7229.2025.14.14

Keywords:

Li-Fraumeni syndrome, Osteosarcoma, TP53 pathogenic variant, Social support, Palliative care

Abstract

We report the case of a woman in her 20s who developed osteosarcoma in the right iliac bone with germline variants in the TP53 gene (TP53: c.220Y＞C). She was referred to a university hospital and imaging studies and biopsy led to a diagnosis of Li-Fraumeni syndrome. After she underwent proton-beam therapy combined with chemotherapy along with weekly hyperthermia, she had been referred to our institution for easier access since 20XX+6. She noticed ipsilateral gluteal pain and swelling in 20XX+8. Imaging and histopathology were consistent with recurrence of the pre-existing osteosarcoma. The palliative interventions enabled her to stay at home; however, her pain consequently exacerbated in 20XX+9. She was admitted emergently, and she died after several days.

References

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Published

2025-11-28

Issue

Vol. 14 (2025)

Section

Articles

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Treatment Experience of Pelvic Osteosarcoma Arising in Li-Fraumeni Syndrome. (2025). Journal of Analytical Oncology, 14, 88-95. https://doi.org/10.30683/1927-7229.2025.14.14

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