Notable Intestinal Obstruction Caused by Malignancy Originating from the Proximal Region of the Ascending Colon and the Caecum: A Case Study and Literature Review
- Authors
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Victor Ikechukwu Canice Nwagbara
Department of Surgery, University of Calabar and University of Calabar Teaching Hospital, Calabar, Nigeria -
John Adi Ashindoitiang
Department of Surgery, University of Calabar and University of Calabar Teaching Hospital, Calabar, Nigeria -
Theophilus Ipeh Ugbem
Department of Pathology, University of Calabar and University of Calabar Teaching Hospital, Calabar, Nigeria -
Joseph Stephen Ukam
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria -
Joseph Esien Kooffreh
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria -
Itunu Oluwadara Adekanye
Department of Surgery, University of Calabar Teaching Hospital, Calabar, Nigeria -
Maurice Efana Asuquo
Department of Surgery, University of Calabar and University of Calabar Teaching Hospital, Calabar, Nigeria
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- Keywords:
- Proximal ascending colon, caecum, cancer, intestinal obstruction, grossly dilated caecum, incompetent ileo-caecal valve, resection
- Abstract
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Intestinal obstruction is a significant medical condition marked by an impediment in the bowel’s capacity to eliminate waste. This condition is characterized by a blockage that hinders digestion and the regular expulsion of waste, which can be attributed to either functional or mechanical factors. A malignant bowel obstruction is frequently observed as a complication in advanced cancer cases, particularly those affecting the digestive tract. A 59 year old male presented with a one-month history characterized by infrequent bowel movements, abdominal distension and pain. Following a comprehensive clinical and imaging studies, a diagnosis of intestinal obstruction was established. The presence of a colonic tumour located in the proximal segment of the ascending colon and caecum, accompanied by a significantly dilated caecum displaying an incompetent ileo-caecal valve and a distended ileum, constituted the indication for a right hemicolectomy. The postoperative course was unremarkable. Ultimately, histopathological analysis confirmed a definitive diagnosis of colon adenocarcinoma. Colonic cancer situated in the proximal ascending colon and the adjacent caecum is uncommon and may manifest as an intestinal obstruction. In appropriate circumstances, right hemicolectomy is considered the preferred therapeutic approach. Early detection and intervention which can be enhanced through targeted screening, are advisable to avert the complications associated with advanced colonic tumours.
- References
-
[1] Tuca A, Guell E, Martinez-Losada E, Codorniv N. Malignant bowel obstruction in advanced cancer patients: epidemiology, management and factors influencing spontaneous resolution. Cancer Management and Research 2012; 4: 159-169.
[2] Shanthi PS, Kawarat VC, Peranbu L. Ascending colon malignancy presenting as large bowel obstruction: a rare case report. Int Surg J 2023; 10(4): 744-746.
[3] Xie X, Zhou Z, Soug Y, Wang W, Dang C, Zhang H. Differences between carcinoma of the caecum and ascending colon: Evidence based on clinical and embryological data. Int J Oncol 2018; 53: 87-98.
[4] Asuquo ME, Inyang A, Nwagbara V, Jibril P. Malignant large bowel obstruction. Nigerian Journal of Surgical sciences 2005; 15(2): 67-70.
[5] Muldoon RL. Malignant large bowel obstruction. Clin Colon Rectal Surg 2021; 34: 251-261.
[6] Ashindoitiang JA, Nwagbara VIC, Odoks R, Asuquo ME. Coloduodenal fistula -An uncommon finding in a man with malignant colonic obstruction. Journal of Medical Case Reports and Case Series 2024; 5(9): 1-4.
[7] Yoo R-N, Cho H-M, Kye BH. Management of obstructed colon cancer: current status, obstacles and future directions. World J Gastrointest Oncol 2021; 13(12): 1850-1862.
[8] Abramov R, Mansour S, Khuri S. Synchronous colon cancer presenting as a different concomitant surgical emergency: case report and literature review. Hellevic Journal of Surgery 2020; 92: 182-185.
[9] Szostek J, Serafin M, Maka M Jablonska B, Mroweic S. Right-sided versus left-sided colon cancer – A 5-year single-centre observational study. Cancers 2025; 17: 537.
[10] Kim Y, Kim MK, Lee S. A comparative genomic analysis of left-sided and right-sided colon cancer using real-world data from AACR project GENIE BPC dataset. Am J Cancer Res 2025; 15(9): 4182-4194.
[11] Cozac-Szoke A-R, Cotoi OS, Mauer U, Steinestel K, Aindt A. Integrated molecular profiling of colorectal cancer by tumour location: Evidence from a Real-World Cohort with primary and metastatic samples. Cancer (Basel) 2026; 18(4): 666.
[12] Salem ME, Weinberg BA, Xiu J et al. Comparative molecular analysis of left-sided colon, right-sided colon and rectal cancers. Oncotarget 2017; 8(49): 86356-86368.
[13] Gruia C, Foarfa C, Streba L, Manesui P. Synchronous carcinoma of the ascending colon and caecum. Rom J Morphol Embryol 2011; 52(4); 1369-1375.
[14] Manalu EPA, Petrus G. Synchronous colorectal cancer: a case report. Int Surg J 2023; 10(10): 1680-1683.
[15] Lee BC, Yu CS, Kim J, Lee JL, Kim CW, Yoon YS, Park IJ, Lein S, Kim JC. Clinicopathological features and surgical options for synchronous colorectal cancer. Medicine (Baltimore) 2017; 96(9): e6224.
[16] Lam AKY, Chan SS, Leung M. Synchronous colorectal tumour: Clinical, pathological and molecular implications. World J Gastroenterol 2014; 20(22): 6815-6820.
[17] Frager d, Rovno HD, Baer JW, Bashist B, Friedman M. Preoperative evaluation of colonic obstruction with CT. Abdom Imaging 1998; 23(2): 141-146.
[18] Fleming M, Ravula S, Tatishchev SF, Wang H. Colorectal carcinoma: pathologic aspects. J Gastrointest Oncol 2012; 3(3): 153-173.
[19] Hussain MI, Piozzi GN, Sakib N, Duhoky R, Carannante F, Khan JS. Laparoscopic versus open emergency surgery for right colon cancers. Diagnostics 2024; 14:407.
[20] Mahmoud Y, Thiagarajan V, Jihad Y, Ranganatha A, Khalid F, Essani B. Comparing the outcome of laparoscopic versus open surgery for colorectal cancer: A systematic review and meta-analysis. Cureus 2025; 17(8): e90687.
[21] Chen W, Tan XP, Ye JW,liu Q, Zeng Q, Wang L et al. Effect of bowel obstruction on stage IV colorectal cancer. Mol Clin Oncol 2014; 2: 308-312.
[22] Suan MAM, Tan WL, Soelar SA, Ismail I, Hassan MRA. Intestinal obstruction prediction of poor prognosis in colorectal cancer. Epidemol Health 2015; 37: e2015017.
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- 2026-04-24
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