logo

Analysis of Kinetics and Efficacy of Anti-Cancer via Oxygen-Enhanced Photodynamic Therapy

Authors

  • Jui-Teng Lin

    New Vision Inc. Taipei, Taiwan

  • Kuo-Ti Chen

    Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan

  • Hsia-Wei Liu

    Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan

DOI:

https://doi.org/10.6000/1929-2279.2018.07.01.2

Keywords:

Photodynamic therapy, Cancer therapy, Photosensitizers, Reactive oxygen species, Cell viability, Threshold dose, Modeling.

Abstract

Photodynamic therapy (PDT has been widely used in many medical applications. PDT for anti-cancer is one of the clinically important subjects. This study will analyze the photochemical kinetics and the efficacy of anti-cancer via the critical factors including: the concentrations of photosensitizers and oxygen in the treated target, the exposure time, intensity and does (energy) of the light applied to the target. To achieve high efficacy, one requires the oxygen source term to re-supply the depletion of oxygen and photosensitizers. Higher light intensity has faster rising curve of the efficacy, but it reaches the same steady-state value as that of low intensity. The efficacy follows the Bunsen-Roscoe law (BRL) of reciprocity only when there is no oxygen source term. Higher initial concentration of oxygen and photosensitizers, C0, always provide higher efficacy. To achieve the same efficacy, minimum dose and/or less exposure time for accelerated procedure may be achieved by using a higher intensity (but same dose) for the case of P=0. However, with P>0, higher intensity requires a higher fluence to achieve the same efficacy and it does not follow the BRL reciprocity law.

References

Lin JT, Chen KT, Liu HW. Progress of nanotechnology for phototherapy: Fundamentals and Applications. Med Devices Diagn Eng 2017. https://doi.org/10.15761/MDDE.1000124

Lin JT, Chiang S, Lin GH, et al. In vitro photothermal destruction of cancer cells using gold nanorods and pulsed-train near-infrared lase. J Nanomaterials 2012; article ID 861385. https://doi.org/10.1155/2012/861385

Lin JT. Analysis of the efficiency of photothermal and photodynamic cancer therapy via nanogolds and photosensitizers. J Cancer Research Update 2017: 12-18. https://doi.org/10.6000/1929-2279.2017.06.01.2

Choi SS, Lee HK, Chae HS. Synergistic in vitro photodynamic antimicrobial activity of methylene blue and chitosan against Helicobacter pylori 26695 Photodiag Photodany Therapy 2014; 11: 526-532.

Wang YH, Chen SP, Liao AH, et al. Synergic delivery of gold nanorods using multifunctional microsbubbles for enhanced plasmonic photothermal therapy. Scientific Report 2014: 5685. doi:10.1038/srep0585.

Shirata C, Kaneko J, Inagaki Y, et al. Near-infrared photothermal/photodynamic therapy with indocyanine green induces apoptosis of hepatocellular carcinoma cells through oxidative stress. Scientific Reports 2017; 7. Article number: 13958. https://doi.org/10.1038/s41598-017-14401-0

Lin JT. Lin-scaling-laws for optimal efficacy in photo-biological systems versus Arndt-Schulz-Law and Bunsen-Roscoe law. Med Devices Diagn Eng 2018; 3: 120-13. doi: 10.15761/MDDE.1000125.

Lin JT. Efficacy S-formula and kinetics of oxygen-mediated (type-II) and non-oxygen-mediated (type-I) corneal cross-linking. Ophthalmology Research 2018; 8(1): 1-11. Article no.OR.39089. DOI : 10.9734/OR/2018/39089.

Foster TH, Murant RS, Bryant RG, et al, Oxygen consumption and diffusion effects in photodynamic therapy. Radiat Res 1991; 126: 296-303.

Hu XH, Feng Y, Lu JQ, et al. Modeling of a Type II photofrin-mediated photodynamic therapy process in a heterogeneous tissue thantom. Photochem Photobiol 2005; 81: 1460-1468.

Wang KKH, Finlay JC, Busch TM, et al. Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling. Journal of Biophotonics 2010; 3(5-6): 304-318.

Zhu TC, Finlay JC, Zhou X, et al. Macroscopic modeling of the singlet oxygen production during PDT. Proc SPIE 2007; 6427: 6427O81-6427O812.

Zhu TC, Kim MM, Ong YH, et al. A summary of light dose distribution using an IR navigation system for Photofrin-mediated pleural PDT. Proc SPIE 2017; 10047. https://doi.org/10.1117/12.2253027

Downloads

Published

2018-08-13

Issue

Vol. 7 No. 1 (2018)

Section

Articles

How to Cite

Analysis of Kinetics and Efficacy of Anti-Cancer via Oxygen-Enhanced Photodynamic Therapy . (2018). Journal of Cancer Research Updates, 7(1), 21-26. https://doi.org/10.6000/1929-2279.2018.07.01.2

Similar Articles

141-150 of 221

You may also start an advanced similarity search for this article.