An Investigation to Study the Role of Novel Rhenium Compounds on Endometrial Uterine Cancer Cell Lines

• Christopher Krauss

  Department of Chemistry, Morgan State University, Baltimore, MD 21251, USA

• Chelsey Aurelius

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Kayla Johnston

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Victoria Bartlette

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Sherrita Gavin

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Jazmine Cuffee

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Satyendra Banerjee

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Sarah Wiseniewsky

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

• Santosh Mandal

  Department of Chemistry, Morgan State University, Baltimore, MD 21251, USA

• Hirendra Nath Banerjee

  Department of Natural, Pharmacy and Health Sciences, Elizabeth City State University Campus of the University of North Carolina, Elizabeth City, NC 27909, USA

Endometrial cancer of the uterus is highly malignant with an increase rate of morbidity and mortality in both childbearing age and postmenopausal women. Rhenium compounds have been shown to have therapeutic properties against various cancers both in vitro cell lines and in vivo animal models. In this in vitro study, we investigated the effects of a novel group of Rhenium ligands on a uterine cancer cell line. Our initial results showed that these compounds are cytotoxic, induces apoptosis and prevents tubulin polymerization in these uterine cancer cell lines, we also found these novel Rhenium compounds to be noncytocidal to healthy human blood lymphocyte cells, thus proving their safety and efficacy in future translational studies.

Collery P, Desmaele D, Vijaykumar V. Design of Rhenium Compounds in Targeted Anticancer Therapeutics. Curr Pharm Des 2019; 25(31): 3306-3322. https://doi.org/10.2174/1381612825666190902161400

Parson C, Smith V, Krauss C, Banerjee HN, Reilly C, Krause JA, et al. Anticancer Properties of Novel Rhenium Pentylcarbanato Compounds against MDA-MB-468(HTB-132) Triple Node Negative Human Breast Cancer Cell Lines. Br J Pharm Res 2015; 4(3): 362-367. https://doi.org/10.9734/BJPR/2014/4697

Knopf KM, Murphy BL, MacMillan SN, Baskin JM, Barr MP, Boros E, et al. In vitro Anticancer Activity and in vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes. J Am Chem Soc 2017; 139(40): 14302-14314. https://doi.org/10.1021/jacs.7b08640

Braun MM, Overbeek-Wager EA, Grumbo RJ. Diagnosis and Management of Endometrial Cancer. Am Fam Physician 2016; 93(6): 468-74.

Moore K, Brewer MA. Endometrial Cancer: Is This a New Disease? Am Soc Clin Oncol Educ Book 2017; 37: 435-442. https://doi.org/10.14694/EDBK_175666

Wilder PT, Weber DJ, Winstead A, Parnell S, Hinton TV, Stevenson M, et al. Unprecedented anticancer activities of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells. Mol Cell Biochem 2018; 441(1-2): 151-163. https://doi.org/10.1007/s11010-017-3181-z

Yang J, Zhao JX, Cao Q, Hao L, Zhou D, Gan Z, et al. Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium(I) Complex. ACS Appl Mater Interfaces 2017; 9(16): 13900-13912. https://doi.org/10.1021/acsami.7b01764

Estrada LD, Duran E, Cisterna M, Echeverria C, Zheng Z, Borgna V, et al. The cluster

Martínez-Lillo J, Mastropietro TF, Lappano R, Madeo A, Alberto ME, Russo N, et al. Rhenium(IV) compounds inducing apoptosis in cancer cells. Chem Commun (Camb) 2011; 47(18): 5283-5. https://doi.org/10.1039/c1cc11038a

Yang J, Zhao JX, Cao Q, Hao L, Zhou D, Gan Z, et al. Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium(I) Complex. ACS Appl Mater Interfaces 2017; 9(16): 13900-13912. https://doi.org/10.1021/acsami.7b01764

Parson C, Smith V, Krauss C, Banerjee HN, Reilly C, Krause JA, et al. The effect of novel rhenium compounds on lymphosarcoma, PC-3 prostate and myeloid leukemia cancer cell lines and an investigation on the DNA binding properties of one of these compounds through electronic spectroscopy. J Bioprocess Biotech 2013; 4(1): 141.

Henley SJ, Miller JW, Dowling NF, Benard VB, Richardson LC. Uterine Cancer Incidence and Mortality - United States, 1999-2016. MMWR Morb Mortal Wkly Rep 2018; 67(48): 1333-1338. https://doi.org/10.15585/mmwr.mm6748a1

Kravchenko J, Akushevich I, Rhew SH, Agarwal P, Lyerly HK. Uterine Cancer Mortality in White and African American Females in Southeastern North Carolina. J Environ Public Health 2020; 2020: 6734031. https://doi.org/10.1155/2020/6734031

Jones NL, Huang Y, Chatterjee S, Tergas AI, Burke WM, Hou JY, et al. Patterns of care and outcomes for women with uterine cancer and ovarian metastases. Int J Gynecol Cancer 2019; 29(2): 365-376. https://doi.org/10.1136/ijgc-2018-000047

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