The Biological Role of Cervical Cancer Suppressor 3 (CCS-3): Literature Review

Abstract

CCS-3 is one of the isoforms of eEF1A1, the key protein of the translation elongation step. Discovered in 2006, it has been the subject of some studies on human cervical cancer cell lines and cervical cancer samples. These studies brought to identify its probable role as a transcriptional co-repressor but other functions are currently unknown. It has also been shown that it is able to inhibit cell growth and induce apoptosis in the tumor cells that downregulate it. Further studies could highlight its functions and its possible usefulness as a tumor marker. This review aims to brief the research about CCS-3 that has been carried out so far.