Virchow-Troisier's Node: A Review


  • Sajad Ahmad Salati Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia
  • Saleh Alsuwaydani Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia



Virchow-Troisier's node, Troisier’s sign, Virchow’s node, Metastasis, Eponymous sign, Horner’s syndrome


Virchow-Troisier's node is an eponymous term referring to the enlargement of the left supraclavicular lymph node. It is a significant physical finding that generally indicates the late manifestation of a variety of malignancies. This review article briefly revisits the historical background, epidemiology, anatomical routes of metastasis, clinical presentation, differential diagnosis, and clinical significance of Virchow-Troisier's node.


Morgenstern L. The Virchow-Troisier node: a historical note. Am J Surg 1979; 138(5): 703. DOI:

Karamanou M, Laios K, Tsoucalas G, Machairas N, Androutsos G. Charles-Emile Troisier (1844-1919) and the clinical description of signal node. J BUON 2014; 19(4): 1133-5.

Adler C, Lubner MG, Menias CO, Lubner SJ, Dahiya N. What's in a node? The clinical and radiologic significance of Virchow's node. Abdom Radiol (NY) 2022; 47(6): 2244-2253. DOI:

Schultz M. Rudolf Virchow. Emerg Infect Dis 2008; 14(9): 1480-1. DOI:

Eisenberg L. Rudolf Ludwig Karl Virchow, where are you now that we need you? Am J Med 1984; 77(3): 524-32. DOI:

Drotman DP. Emerging infectious diseases: a brief biographical heritage. Emerg Infect Dis 1998; 4(3): 372-3. DOI:

Brown TM, Fee E. Rudolf Carl Virchow: medical scientist, social reformer, role model. Am J Public Health 2006; 96(12): 2104-5. DOI:

Mizutani M, Nawata S, Hirai I, Murakami G, Kimura W. Anatomy and histology of Virchow's node. Anat Sci Int 2005; 80(4): 193-8. DOI:

Zdilla MJ, Aldawood AM, Plata A, Vos JA, Lambert HW. Troisier sign and Virchow node: the anatomy and pathology of pulmonary adenocarcinoma metastasis to a supraclavicular lymph node. Autops Case Rep 2019; 9(1): e2018053. DOI:

Cervin JR, Silverman JF, Loggie BW, Geisinger KR. Virchow's node revisited. Analysis with clinicopathologic correlation of 152 fine-needle aspiration biopsies of supraclavicular lymph nodes. Arch Pathol Lab Med 1995; 119(8): 727-30.

Gupta N, Rajwanshi A, Srinivasan R, Nijhawan R. Pathology of supraclavicular lymphadenopathy in Chandigarh, north India: an audit of 200 cases diagnosed by needle aspiration. Cytopathology 2006; 17(2): 94-6. DOI:

Nasuti JF, Mehrotra R, Gupta PK. Diagnostic value of fine-needle aspiration in supraclavicular lymphadenopathy: a study of 106 patients and review of literature. Diagn Cytopathol 2001; 25(6): 351-5. DOI:

Sandal R, Dhiman P, Sharma P, Gupta M. Virchow's node (Troisier's sign) and testicular carcinoma. QJM 2022; 115(11): 754-755. DOI:

Kew MC. Virchow-Troisier's lymph node in hepatocellular carcinoma. J Clin Gastroenterol 1991; 13(2): 217-9. DOI:

López F, Rodrigo JP, Silver CE, Haigentz M Jr, Bishop JA, Strojan P, Hartl DM, Bradley PJ, Mendenhall WM, Suárez C, Takes RP, Hamoir M, Robbins KT, Shaha AR, Werner JA, Rinaldo A, Ferlito A. Cervical lymph node metastases from remote primary tumor sites. Head Neck 2016; 38(Suppl 1): E2374-85. DOI:

Viacava EP, Pack GT. Significance of supraclavicular signal node in patients with abdominal and thoracic cancer—a study of one hunded and twenty-two cases. Arch Surg 1944; 48: 109-199. DOI:

Galloy AC, Christophe JL, Cambier E, Petein M, Verhelst D. Virchow-Troisier's node in a haemodialysed patient: it is not always cancer. Nephrol Dial Transplant 2005; 20(3): 647-9. DOI:

Duman U, Yeşıl C, Gündüz M, Denız IK. Isolated left supraclavicular hydatid cyst mimicking Virchow's node. Turk J Gastroenterol 2012; 23(5): 612-4. DOI:

Siosaki MD, Souza AT. Images in clinical medicine. Virchow's node. N Engl J Med 2013; 368(6): e7. DOI:

Mondal RK, Dutta A, Basu K, Chakraborti S. Virchows node: rare presentation of childhood hepatocellular carcinoma. Indian J Pediatr 2005; 72(2): 177-8. DOI:

Schwarz KO, Schwartz IS, Marchevsky A. Virchow-Troisier's lymph node as the presenting sign of hepatocellular carcinoma. Mt Sinai J Med 1982; 49(1): 59-62.

Rahman M, Nakayama K, Rahman MT, Katagiri H, Ishibashi T, Miyazaki K. Enlarged Virchow's node as an initial complaint of serous ovarian adenocarcinoma. Eur J Gynaecol Oncol 2012; 33(5): 546-8.

Maslovsky I, Gefel D. Virchow's node and Horner's syndrome. Am J Med 2006; 119(2): 180-1. DOI:

Werner RA, Andree C, Javadi MS, Lapa C, Buck AK, Higuchi T, Pomper MG, Gorin MA, Rowe SP, Pienta KJ. A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging. Urology 2018; 117: 18-21. DOI:

Cham D, Henderson R, Conti PS. Virchow's Node on F-18 FDG PET/CT. Clinical Nuclear Medicine 2004; 29(11): 770-772. DOI:

de la Riva-Pérez PA, García-Gómez FJ, Buján-Lloret C, Calvo-Morón MC, Castro-Montaño J. Virchow Node from Prostate Carcinoma by 18F-Choline PET/CT. Clin Nucl Med 2018; 43(4): 271-272. DOI:




How to Cite

Salati, S. A., & Alsuwaydani, S. (2023). Virchow-Troisier’s Node: A Review. Journal of Analytical Oncology, 12, 24–28.




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