Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis
DOI:
https://doi.org/10.30683/1927-7229.2023.12.07Keywords:
Breast cancer, uterine cancer, uterine metastasis, hysterectomy, immunohistochemistry, invasive lobular breast carcinoma, invasive ductal cell carcinomaAbstract
Breast cancer can metastasize to a wide range of organs, but reports about uterine metastases are rare. The current article systematically analyzes 55 patients reported in peer-reviewed literature from 2010–2022 with respect to nine variables, including: [i] age of the patient; [ii] clinical presentation of uterine metastasis; [iii] precise location of metastasis; [iv] primary (breast) cancer histopathology; [v] imaging modality utilized for detection of metastasis; [vi] timing of appearance of metastases: synchronous or metachronous; [vii] immunochemistry markers; [viii] management; and [ix] survival. Uterine metastases may appear in synchronous or metachronous fashion and may be asymptomatic or have symptoms like abnormal vaginal bleeding. Treatment of uterine metastases usually comprises of total abdominal hysterectomy with bilateral salpingo-oophorectomy along with chemotherapy. The long-term prognosis is unclear, but due to the development of metastases in other bodily parts, cases frequently have a poor outcome.
References
Di Micco R, Santurro L, Gasparri ML, Zuber V, Fiacco E, Gazzetta G, Smart CE, Valentini A, Gentilini OD. Rare sites of breast cancer metastasis: a review. Transl Cancer Res 2019; 8(Suppl 5): S518-S552. https://doi.org/10.21037/tcr.2019.07.24 DOI: https://doi.org/10.21037/tcr.2019.07.24
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68(6): 394-424. https://doi.org/10.3322/caac.21492 DOI: https://doi.org/10.3322/caac.21492
Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA. American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline. CA Cancer J Clin 2016; 66(1): 43-73. https://doi.org/10.3322/caac.21319 DOI: https://doi.org/10.3322/caac.21319
Khatcheressian JL, Hurley P, Bantug E, Esserman LJ, Grunfeld E, Halberg F, Hantel A, Henry NL, Muss HB, Smith TJ, Vogel VG, Wolff AC, Somerfield MR, Davidson NE. American Society of Clinical Oncology. Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 2013; 31(7): 961-65. https://doi.org/10.1200/JCO.2012.45.9859 DOI: https://doi.org/10.1200/JCO.2012.45.9859
Bogliolo S, Morotti M, ValenzanoMenada M, Fulcheri E, Musizzano Y, Casabona F. Breast cancer with synchronous massive metastasis in the uterine cervix: a case report and review of the literature. Arch Gynecol Obstet 2010; 281(4): 769-73. https://doi.org/10.1007/s00404-009-1264-0 DOI: https://doi.org/10.1007/s00404-009-1264-0
D'souza MM, Sharma R, Tripathi M, Saw SK, Anand A, Singh D, Mondal A. Cervical and uterine metastasis from carcinoma of breast diagnosed by PET/CT: an unusual presentation. ClinNucl Med 2010; 35(10): 820-23. https://doi.org/10.1097/RLU.0b013e3181ef0b1b DOI: https://doi.org/10.1097/RLU.0b013e3181ef0b1b
Hara F, Kiyoto S, Takabatake D, Takashima S, Aogi K, Ohsumi S, Teramoto N, Nishimura R, Takashima S. Endometrial Metastasis from Breast Cancer during Adjuvant Endocrine Therapy. Case Rep Oncol 2010; 3(2): 137-41. https://doi.org/10.1159/000313921 DOI: https://doi.org/10.1159/000313921
Hooker AB, Radder CM, van de Wiel B, Geenen MM. Metastasis from breast cancer to an endometrial polyp; treatment options and follow-up. Report of a case and review of the literature. Eur J Gynaecol Oncol 2011; 32(2): 228-30.
Abaid LN, Rhee JM, Rausei-Mills V, Lim J, Police AM, Goldstein BH. Metastatic lobular breast carcinoma infiltrating a uterine leiomyoma. J Minim Invasive Gynecol 2011; 18(5): 674-77. https://doi.org/10.1016/j.jmig.2011.06.008 DOI: https://doi.org/10.1016/j.jmig.2011.06.008
Dirican A, Kucukzeybek Y, Somali I, Erten C, Demir L, Can A, et al. Micro-metastases into the uterine leiomyoma from invasive ductal breast cancer under adjuvant tamoxifen therapy: case report. Eur J Gynaecol Oncol 2012; 33(6): 652-55.
vanMeurs HS, Dieles JJ, Stel HV. A uterine leiomyoma in which a leiomyosarcoma with osteoclast-like giant cells and a metastasis of a ductal breast carcinoma are present. Ann Diagn Pathol 2012; 16(1): 67-70. https://doi.org/10.1016/j.anndiagpath.2010.11.010 DOI: https://doi.org/10.1016/j.anndiagpath.2010.11.010
Horikawa M, Mori Y, Nagai S, Tanaka S, Saito S, Okamoto T. Metastatic breast cancer to the uterine cervix mimicking a giant cervical leiomyoma. Nagoya J Med Sci 2012; 74(3-4): 347-51.
Arslan D, Tural D, Tatlı AM, Akar E, Uysal M, Erdoğan G. Isolated uterine metastasis of invasive ductal carcinoma. Case Rep Oncol Med 2013; 2013: 793418. https://doi.org/10.1155/2013/793418 DOI: https://doi.org/10.1155/2013/793418
Muñoz-Iglesias J, Uña-Gorospe J, Allende-Riera A, De Sequera-Rahola M, Cárdenas-Negro C. Unsuspected uterine metastasis of breast carcinoma diagnosed by 18F-FDG PET/CT. ClinNucl Med 2013; 38(11): e441-42. https://doi.org/10.1097/RLU.0b013e318292a73b DOI: https://doi.org/10.1097/RLU.0b013e318292a73b
Alheeti S, Qureshi A, Ansari N, Murphy JF. Metastatic Breast Cancer of the Cervix Presenting in Labor. Bahrain Med Bull 2014; 36(2): 112-13. DOI: https://doi.org/10.12816/0004491
Binstock A, Smith AL, Olawaiye AB. Recurrent breast carcinoma presenting as postmenopausal vaginal bleeding: A case report. Gynecol Oncol Rep 2013; 10: 38-40. https://doi.org/10.1016/j.gynor.2013.06.003 DOI: https://doi.org/10.1016/j.gynor.2013.06.003
Bezpalko K, Mohamed MA, Mercer L, McCann M, Elghawy K, Wilson K. Concomitant endometrial and gallbladder metastasis in advanced multiple metastatic invasive lobular carcinoma of the breast: A rare case report. Int J Surg Case Rep 2015; 14: 141-45. https://doi.org/10.1016/j.ijscr.2015.07.036 DOI: https://doi.org/10.1016/j.ijscr.2015.07.036
Haeri H, Movarrei F, Shaker G. Metastatic breast cancer to uterine leiomyoma: case report. Tehran Univ Med J 2015; 73(5): 391-95.
Huo Z, Gao Y, Zuo W, Zheng G, Kong R. Metastases of basal-like breast invasive ductal carcinoma to the endometrium: A case report and review of the literature. Thorac Cancer 2015; 6(4): 548-52. https://doi.org/10.1111/1759-7714.12195 DOI: https://doi.org/10.1111/1759-7714.12195
Pekindil G, Solmaz Hasdemir P, Tan A, Goksel G. Breast Cancer with Silent Metas-tasis to Uterine Cervix. J Clin Anal Med 2015; 6(suppl 5): 647-49
Toyoshima M, Iwahashi H, Shima T, Hayasaka A, Kudo T, Makino H, Igeta S, Matsuura R, Ishigaki N, Akagi K, Sakurada J, Suzuki H, Yoshinaga K. Solitary uterine metastasis of invasive lobular carcinoma after adjuvant endocrine therapy: a case report. J Med Case Rep 2015; 9: 47. https://doi.org/10.1186/s13256-014-0511-6 DOI: https://doi.org/10.1186/s13256-014-0511-6
Lokadasan R, Ratheesan K, Sukumaran R, Nair SP. Metastatic lobular carcinoma of breast mimics primary cervix carcinoma: two case reports and a review of the literature. Ecancermedicalscience 2015; 9: 571. https://doi.org/10.3332/ecancer.2015.571 DOI: https://doi.org/10.3332/ecancer.2015.571
Waks AG, Lennon J, Yadav BS, Hwang H, dSchapirael Carmen M, Johnson NB, Reynolds K, Schapira L, Gilman PB, Overmoyer B. Metastasis to the Cervix Uteri 15 Years After Treatment of Lobular Carcinoma of the Breast. Semin Oncol 2015; 42(4): e81-94. https://doi.org/10.1053/j.seminoncol.2015.07.002 DOI: https://doi.org/10.1053/j.seminoncol.2015.07.002
Razia S, Nakayama K, Tsukao M, Nakamura K, Ishikawa M, Ishibashi T, Ishikawa N, Sanuki K, Yamashita H, Ono R, Hossain MM, Minamoto T, Kyo S. Metastasis of breast cancer to an endometrial polyp, the cervix and a leiomyoma: A case report and review of the literature. Oncol Lett 2017; 14(4): 4585-92. https://doi.org/10.3892/ol.2017.6822 DOI: https://doi.org/10.3892/ol.2017.6822
Seo SY, Shin JY, Ji YI. Metastatic uterine cancer looking as cervical fibroid in recurrent breast cancer woman: a case report. ObstetGynecol Sci 2017; 60(5): 481-84. https://doi.org/10.5468/ogs.2017.60.5.481 DOI: https://doi.org/10.5468/ogs.2017.60.5.481
Hajal E, Dabaj E, Kassem M, Snaifer E, Ghandour F. Endometrial Metastasis from a Breast Carcinoma Simulating a Primary Uterine Malignancy. J Adenocarcinoma 2017; 2: 1. https://doi.org/10.21767/2572-309X.100016
Chupryna E, Ganovska A, Kirilova I, Kovachev S, Baytchev G. Endometrial and cervical metastases leading to the diagnosis of a primary breast cancer: A case report. Int J Surg Med 2017; 3(4): 253-56. DOI: https://doi.org/10.5455/ijsm.endometrial-and-cervical-metastases-primary-breast-cancer
Trihia H, Gavresea T, Novkovic N. Lobular carcinoma metastasis to endometrial polyp 19 years after primary diagnosis: a report of an exceptional case. J Clin Obstet Gynecol Infertil 2017; 1(4): 1019.
Akinpeloye A, Satti M, Congdon D, BoikeG . Breast Cancer Masquerades as an Endometrial Cancer. Obstet Gynecol Cases Rev 2017; 4: 103. https://doi.org/10.23937/2377-9004/1410103 DOI: https://doi.org/10.23937/2377-9004/1410103
Akhtar A, Ratra A, Puckett Y, Sheikh AB, Ronaghan CA. Synchronous Uterine Metastases from Breast Cancer: Case Study and Literature Review. Cureus 2017; 9(11): e1840. https://doi.org/10.7759/cureus.1840 DOI: https://doi.org/10.7759/cureus.1840
Abdalla AS, Lazarevska A, Omer MM, Tan E, Asaad A, Sathananthan S. Metastatic Breast Cancer to the Cervix Presenting with Abnormal Vaginal Bleeding During Chemotherapy: A Case Report and Literature Review. Chirurgia (Bucur) 2018; 113(4): 564-70. https://doi.org/10.21614/chirurgia.113.4.564 DOI: https://doi.org/10.21614/chirurgia.113.4.564
Berger AA, Matrai CE, Cigler T, Frey MK. Palliative hysterectomy for vaginal bleeding from breast cancer metastatic to the uterus. Ecancermedicalscience 2018; 12: 811. https://doi.org/10.3332/ecancer.2018.811 DOI: https://doi.org/10.3332/ecancer.2018.811
Briki R, Cherif O, Bannour B, Hidar S, Boughizane S, Khairi H. Uncommon metastases of invasive lobular breast cancer to the endometrium: a report of two cases and review of the literature. Pan Afr Med J 2018; 30: 268. https://doi.org/10.11604/pamj.2018.30.268.16208 DOI: https://doi.org/10.11604/pamj.2018.30.268.16208
Thouvenot A, Bizet Y, Baccar LS, Lamuraglia M. Primary breast cancer relapse as metastasis to the cervix uteri: A case report. Mol Clin Oncol 2018; 9(1): 96-97. https://doi.org/10.3892/mco.2018.1627 DOI: https://doi.org/10.3892/mco.2018.1627
Rahmani M, Nili F, Tabibian E. Endometrial Metastasis from Ductal Breast Carcinoma: A Case Report with Literature Review. Am J Case Rep 2018; 19: 494-99. https://doi.org/10.12659/AJCR.907638 DOI: https://doi.org/10.12659/AJCR.907638
Cimpeanu E, Ahmed J, Tricorico G, Bardarov S, Shulimovich M, Lakhi N. Unique presentation of occult breast cancer with uterine cervix metastasis. Clin Case Rep 2019; 7(8): 1573-76. https://doi.org/10.1002/ccr3.2306 DOI: https://doi.org/10.1002/ccr3.2306
Franco-Márquez R, Torres-Gaytán AG, Narro-Martinez MA, Carrasco-Chapa A, Núñez BG, Boland-Rodriguez E. Metastasis of Breast Lobular Carcinoma to Endometrium Presenting as Recurrent Abnormal Uterine Bleeding: A Case Report and Review of Literature. Case Rep Pathol 2019; 2019: 5357194. https://doi.org/10.1155/2019/5357194 DOI: https://doi.org/10.1155/2019/5357194
Homsi MEl, Barakat A, Rammal R, Haidar M. Uterine metastasis from invasive ductal breast carcinoma mimicking fibroid features on MRI and detected by FDG PET/CT: role of SUVmax. Eur J Gynaecol Oncol 2019; 40(6): 1079-82. https://doi.org/10.12892/ejgo4771.2019 DOI: https://doi.org/10.12892/ejgo4771.2019
Silva Fontinele DR, Vieira SC, da Silva Júnior RG, Rodrigues TS. Lobular carcinoma of the breast with metastasis to the uterine cervix. J Can Res Ther 2019; 15: 1411-4. https://doi.org/10.4103/jcrt.JCRT_469_18 DOI: https://doi.org/10.4103/jcrt.JCRT_469_18
Arif SH, Mohammed AA, Mohammed FR. Metastatic invasive lobular carcinoma of the breast to the endometrium presenting with abnormal uterine bleeding; Case report. Ann Med Surg (Lond) 2020; 51: 41-43. https://doi.org/10.1016/j.amsu.2020.01.008 DOI: https://doi.org/10.1016/j.amsu.2020.01.008
Abdallah H, Elwy A, Alsayed A, Rabea A, Magdy N. Metastatic Breast Lobular Carcinoma to Unusual Sites: A Report of Three Cases and Review of Literature. J Med Cases 2020; 11(9): 292-95. https://doi.org/10.14740/jmc3538 DOI: https://doi.org/10.14740/jmc3538
Farkas A, Rigney D, Shenoy V, Nutter K. (Nov 06, 2020). Breast Cancer Metastasis to the Endometrium. Appl Radiol 2020; 49(6): 52-53. DOI: https://doi.org/10.37549/AR2687
Qawasmeh J, A-Hussaini M, Koro S. Invasive Ductal Carcinoma of the Breast with Metastasis to the Uterine Cervix. Clin Case Rep Int 2020; 4: 1172.
Goel S, Sharma PK, Lodha M. A Rare Case of Cervix Metastasis from a Breast Primary. Cancer Ther Oncol Int J 2020; 17(1): CTOIJ.MS.ID.555954. https://doi.org/10.19080/CTOIJ.2020.17.555954 DOI: https://doi.org/10.19080/CTOIJ.2020.17.555954
Danolić D, Marcelić L, Alvir I, Mamić I, Sušnjar L, Rendić-miočević Z, Puljiz M. Rare case of invasive lobular breast cancer metastasis to the endometrium. Lib Oncol 2020; 48(2-3): 116-18. https://doi.org/10.20471/LO.2020.48.02-03.19 DOI: https://doi.org/10.20471/LO.2020.48.02-03.19
Gomez M, Whitting K, Naous R. Lobular breast carcinoma metastatic to the endometrium in a patient under tamoxifen therapy: A case report. SAGE Open Med Case Rep 2020; 8: 2050313X20907208. https://doi.org/10.1177/2050313X20907208 DOI: https://doi.org/10.1177/2050313X20907208
Cochrane E, Kim S, Kudelka A, Burke W. Invasive ductal breast carcinoma metastasis to the cervix: A case review and clinical correlation. Gynecol Oncol Rep 2020; 33: 100616. https://doi.org/10.1016/j.gore.2020.100616 DOI: https://doi.org/10.1016/j.gore.2020.100616
Landolfo C, Musone M, Catinella V, Tralongo P, Pozzati F, Quagliozzi L, Bertoldo V, Muratore M, Paris I, Testa AC. A rare case of uterine metastasis from breast cancer. Ultrasound Obstet Gynecol 2021; 58: 100. VP03.04. https://doi.org/10.1002/uog.24048 DOI: https://doi.org/10.1002/uog.24048
Awazu Y, Fukuda T, Imai K, Yamauchi M, Kasai M, Ichimura T, Yasui T, Sumi T: Uterine metastasis of lobular breast carcinoma under tamoxifen therapy: A case report. Mol Clin Oncol 2021; 15: 266. https://doi.org/10.3892/mco.2021.2428 DOI: https://doi.org/10.3892/mco.2021.2428
Azhar M, Hamdani SAM, Iftikhar J, Ahmad W, Mushtaq S, KalsoomAwan UE. An Unusual Occurrence of Uterine Metastases in a Case of Invasive Ductal Breast Carcinoma. Cureus 2021; 13(11): e19820. https://doi.org/10.7759/cureus.19820 DOI: https://doi.org/10.7759/cureus.19820
Lim L, Wang TY, Lam HB, Chang CL. Massive metastasis of breast cancer to female genital organs. Taiwan J Obstet Gynecol 2021; 60(3): 563-66. https://doi.org/10.1016/j.tjog.2021.03.033 DOI: https://doi.org/10.1016/j.tjog.2021.03.033
Varghese MP, Raju S, Savithri MC, Augustine J, Varghese M. Metastatic Breast Carcinoma to The Uterine Cervix - An Unusual Presentation . Annals of Pathology and Laboratory Medicine 2021; 8(2): C32-34. https://doi.org/10.21276/APALM.2944 DOI: https://doi.org/10.21276/apalm.2944
Dominguez R S, Billod J A. Ovary and Uterus, Rare Sites of Metastases from Breast Cancer: A Case Series. Int J Med Rev Case Rep 2021; 5(6): 79-85. https://doi.org/10.5455/IJMRCR.metastasis-breast-cancer-172-1606462902 DOI: https://doi.org/10.5455/IJMRCR.metastasis-breast-cancer-172-1606462902
Bouvier AS, Panchbhaya N, Brochard C, Marchand E, Mezzadri M, Leveau-Vallier AS, Cornelis F, Benifla JL, Mimoun C. Uterine metastasis from invasive ductal breast carcinoma: A case report with literature review. J Gynecol Obstet Hum Reprod 2021; 50(1): 101993. https://doi.org/10.1016/j.jogoh.2020.101993 DOI: https://doi.org/10.1016/j.jogoh.2020.101993
Kong D, Dong X, Qin P, Sun D, Zhang Z, Zhang Y, Hao F, Wang M. Asymptomatic uterine metastasis of breast cancer: Case report and literature review. Medicine 2022; 101: 41(e31061). https://doi.org/10.1097/MD.0000000000031061 DOI: https://doi.org/10.1097/MD.0000000000031061
Subhas N, Patel PV, Pannu HK, Jacene HA, Fishman EK, Wahl RL. Imaging of pelvic malignancies with in-line FDG PET-CT: case examples and common pitfalls of FDG PET. Radiographics 2005; 25(4): 1031-43. https://doi.org/10.1148/rg.254045155 DOI: https://doi.org/10.1148/rg.254045155
Ma Y, Shao X. Uterine fibroids with positive 18F-FDG PET/CT image and significantly increased CA19-9: A case report. Medicine (Baltimore) 2017; 96(51): e9421. https://doi.org/10.1097/MD.0000000000009421 DOI: https://doi.org/10.1097/MD.0000000000009421
Zaha DC. Significance of immunohistochemistry in breast cancer. World J Clin Oncol 2014; 5(3): 382-92. https://doi.org/10.5306/wjco.v5.i3.382 DOI: https://doi.org/10.5306/wjco.v5.i3.382
Tozbikian GH, Zynger DL. A combination of GATA3 and SOX10 is useful for the diagnosis of metastatic triple-negative breast cancer. Hum Pathol 2019; 85: 221-227. https://doi.org/10.1016/j.humpath.2018.11.005 DOI: https://doi.org/10.1016/j.humpath.2018.11.005
Han JH, Kang Y, Shin HC, Kim HS, Kang YM, Kim YB, Oh SY. Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma. Arch Pathol Lab Med 2003; 127(10): 1330-4. https://doi.org/10.5858/2003-127-1330-MEILNI DOI: https://doi.org/10.5858/2003-127-1330-MEILNI
Cummings MC, Simpson PT, Reid LE, Jayanthan J, Skerman J, Song S, McCart Reed AE, Kutasovic JR, Morey AL, Marquart L, O'Rourke P, Lakhani SR. Metastatic progression of breast cancer: insights from 50 years of autopsies. J Pathol 2014; 232(1): 23-31. https://doi.org/10.1002/path.4288 DOI: https://doi.org/10.1002/path.4288
Lamovec J, Bracko M. Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol 1991; 48(1): 28-33. https://doi.org/10.1002/jso.2930480106 DOI: https://doi.org/10.1002/jso.2930480106
Wahed A, Connelly J, Reese T. E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma. Ann Diagn Pathol 2002; 6(6): 349-51. https://doi.org/10.1053/adpa.2002.36660 DOI: https://doi.org/10.1053/adpa.2002.36660
Varga Z, Mallon E. Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls. Breast Dis 2008-2009; 30: 15-9. https://doi.org/10.3233/BD-2009-0278 DOI: https://doi.org/10.3233/BD-2009-0278
Kowalski PJ, Rubin MA, Kleer CG. E-cadherin expression in primary carcinomasof the breast and its distant metastases. Breast Cancer Res 2003; 5: R217YR222. DOI: https://doi.org/10.1186/bcr651
Rodrigues F, Carneiro F, Lopes C. Uterine metastasis from breast cancer – retrospective analysis of 15 cases. Acta Obstet Ginecol Port 2015; 9(1): 27-33.
Karvouni E, Papakonstantinou K, Dimopoulou C, Kairi-Vassilatou E, Hasiakos D, Gennatas CG, Kondi-Paphiti A. Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. Arch Gynecol Obstet 2009; 279(2): 199-201. https://doi.org/10.1007/s00404-008-0665-9 DOI: https://doi.org/10.1007/s00404-008-0665-9
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