Structured Water and Cancer: Orthomolecular Hydration Therapy
Keywords:Structured water, Cancer, Cellular hydration, Orthomolecular medicine
It is a common practice to envision cancer exclusively as a genetic disease, however, in our perspective, changes in gene expression leading to malignancy are secondary to biochemical disturbances and at its core we consider cancer as a metabolic energetic disease. In this regard, incongruence with the concept of the bioenergetic theory of carcinogenesis, we propose structured water (EZ water), as an element that facilitates the correction of the fundamental energy disruption and the reestablishment of health. The prime approach for this therapy would be to infuse kosmotropic osmolytes by the intravenous route to improve the physiological conditions and promote the reduction of cancer growth with no side effects. By doing so, we could expect that the cells will regain their communication ability with a functioning Ras and p53 proteins and other metabolic and transcription factors. The end goal is to support the cell in overcoming its low-energy anaerobic glycolytic metabolism that favors uncontrolled growth and regain the full energetic potential of oxidative phosphorylation that supports controlled cell division and differentiation. To achieve this goal, we propose the use of metabolic correction to improve the membrane function of the mitochondria. The use of precursors, enzymatic cofactors, and a variety of biological response modifiers which includes structured water and its kosmotropic properties in enzyme dynamics are part of the metabolic correction concept.
National Cancer Institute. What is cancer? Cancer.gov. https://www.cancer.gov/about-cancer/understanding/what-is-cancer. Updated May 5, 2021.
Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN. Brain mitochondrial lipid abnormalities in mice susceptible to spontaneous gliomas. Lipids 2008; 43(10): 951-9. https://doi.org/10.1007/s11745-008-3197-y DOI: https://doi.org/10.1007/s11745-008-3197-y
Seyfried TN, Shelton LM. Cancer as a metabolic disease. NutrMetab (Lond) 2010; 7: 7. https://doi.org/10.1186/1743-7075-7-7 DOI: https://doi.org/10.1186/1743-7075-7-7
Gonzalez MJ, Miranda Massari JR, Duconge J, Riordan NH, Ichim T, Quintero-Del-Rio AI, Ortiz N. The bio-energetic theory of carcinogenesis. Med Hypotheses 2012; 79(4): 433-9. https://doi.org/10.1016/j.mehy.2012.06.015 DOI: https://doi.org/10.1016/j.mehy.2012.06.015
Gonzalez MJ, Olalde J, Rodriguez JR, Rodriguez D, Duconge J. Metabolic Correction and Physiologic Modulation as the Unifying Theory of the Healthy State: The Orthomolecular, Systemic and Functional Approach to Physiologic Optimization. J Orthomol Med 2018; 33(1).
Damadian R. Tumor detection by nuclear magnetic resonance. Science 1971; 171(3976): 1151-3. https://doi.org/10.1126/science.171.3976.1151 DOI: https://doi.org/10.1126/science.171.3976.1151
Davidson RM, Seneff S. The Initial Common Pathway of Inflammation, Disease, and Sudden Death. Entropy 2012; 14: 1399-1442. https://doi.org/10.3390/e14081399 DOI: https://doi.org/10.3390/e14081399
Nicolson GL. Mitochondrial Dysfunction and Chronic Disease: Treatment with Natural Supplements. Integr Med (Encinitas) 2014; 13(4): 35-43.
Gonzalez MJ, Seyfried T, NicolsonG, Barclay B, Matta J, Vasquez A, Agostino D, Olalde J, Duconge J, Hunninghake R, Berdiel MJ, Cintron A. Mitochondrial Correction: A New Therapeutic Paradigm for Cancer and Degenerative Diseases. J Orthomol Med 2018b; 33(4).
Belloni L, Allweiss L, Guerrieri F, Pediconi N, Volz T, Pollicino T, Petersen J, Raimondo G, Dandri M, Levrero M. IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA mini chromosome. J Clin Invest 2012; 122(2): 529-37. https://doi.org/10.1172/JCI58847 DOI: https://doi.org/10.1172/JCI58847
Grigera JR, Andres N, McCarthy AN. The behavior of the hydrophobic effect under pressure and protein denaturation. Biophys J 2010; 98: 1626-1631. https://doi.org/10.1016/j.bpj.2009.12.4298 DOI: https://doi.org/10.1016/j.bpj.2009.12.4298
Combet S, Zanotti JM. Further evidence that interfacial water is the main “driving force” of protein dynamics: A neutron scattering study on perdeuterated C-phycocyanin. Phys Chem Chem Phys 2012; 14: 4927-4934. https://doi.org/10.1039/c2cp23725c DOI: https://doi.org/10.1039/c2cp23725c
Mamontov E, Chu XQ. Water-protein dynamic coupling and new opportunities for probing it at low to physiological temperatures in aqueous solutions. Phys Chem Chem Phys 2012; 14: 11573-11588. https://doi.org/10.1039/c2cp41443k DOI: https://doi.org/10.1039/c2cp41443k
Hwang SG, Lee H S, Lee BC, Bahng G. Effect of Antioxidant Water on the Bioactivities of Cells. International Journal of Cell Biology 2017; 1917239. https://doi.org/10.1155/2017/1917239 DOI: https://doi.org/10.1155/2017/1917239
Pollack GH. The fourth phase of water: Beyond solid, liquid, and vapor. by Gerald H. Pollack. The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor, Ebner & Sons Publishers, 2013; 357 Pages. ISBN 978-0-9626895-4-3
Zheng JM, Chin WC, Khijniak E, Khijniak E Jr, Pollack GH. Surfaces and interfacial water: evidence that hydrophilic surfaces have long-range impact. Adv Colloid Interface Sci 2006; 127(1): 19-27. https://doi.org/10.1016/j.cis.2006.07.002 DOI: https://doi.org/10.1016/j.cis.2006.07.002
Zavrtnik S, Loborec J, Žubčić D, Sabol G.Memory of water–Water as a medium of information transfer. Holistic Approach Environ 2021; 11(1): 23-29. https://doi.org/10.33765/thate.11.1.4 DOI: https://doi.org/10.33765/thate.11.1.4
Montagnier L, Del Giudice E, Aïssa J, Lavallee C, Motschwiller S, Capolupo A, Polcari A, Romano P, Tedeschi A, Vitiello G. Transduction of DNA information through water and electromagnetic waves. Electromagn Biol Med 2015; 34(2): 106-12. https://doi.org/10.3109/15368378.2015.1036072 DOI: https://doi.org/10.3109/15368378.2015.1036072
Elton DC, Spencer PD, Riches JD, Williams ED. Exclusion Zone Phenomena in Water-A Critical Review of Experimental Findings and Theories. Int J Mol Sci 2020; 21(14): 5041. https://doi.org/10.3390/ijms21145041 DOI: https://doi.org/10.3390/ijms21145041
Yamamoto E, Akimoto T, Yasui M, Yasuoka K. Origin of sub diffusion of water molecules on cell membrane surfaces. Sci Rep 2014; 4: 4720. https://doi.org/10.1038/srep04720 DOI: https://doi.org/10.1038/srep04720
Feher J. Quantitative Human Physiology; An Introduction. Elsevier 2012; pp. 134-14. https://doi.org/10.1016/B978-0-12-382163-8.00016-5 DOI: https://doi.org/10.1016/B978-0-12-382163-8.00016-5
Korotkov K. Study of structured water and its biological effects. Int J Complement Alt Med 2019; 12(5): 168-172. https://doi.org/10.15406/ijcam.2019.12.00468 DOI: https://doi.org/10.15406/ijcam.2019.12.00468
Welch GR, Clegg JS. From protoplasmic theory to cellular systems biology: a 150-year reflection. Am J Physiol Cell Physiol 2010; 298(6): C1280-90. https://doi.org/10.1152/ajpcell.00016.2010 DOI: https://doi.org/10.1152/ajpcell.00016.2010
Grba DN, Hirst J. Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation. Nat Struct Mol Biol 2020; 27: 892-900. https://doi.org/10.1038/s41594-020-0473-x DOI: https://doi.org/10.1038/s41594-020-0473-x
Marques M, Batista de Carvalho A, Mamede AP, Dopplapudi A, García Sakai V, Batista de Carvalho L. Role of intracellular water in the normal-to-cancer transition in human cells-insights from quasi-elastic neutron scattering. Structural dynamics (Melville, N.Y.) 2020; 7(5): 054701. https://doi.org/10.1063/4.0000021 DOI: https://doi.org/10.1063/4.0000021
Miskowiec A, Buck ZN, Hansen FY, Kaiser H, Taub H, Tyagi M, Diallo SO, Mamontov E, Herwig KW. On the structure and dynamics of water associated with single-supported zwitterionic and anionic membranes. J Chem Phys 2017; 146(12): 125102. https://doi.org/10.1063/1.4978677 DOI: https://doi.org/10.1063/1.4978677
O’Brien JT, Prell JS, Bush MF, Williams ER. Sulfate ion patterns water at long distance. J Am Chem Soc 2010; 132: 8248-8249. https://doi.org/10.1021/ja1024113 DOI: https://doi.org/10.1021/ja1024113
Collins KD. Charge density-dependent strength of hydration and biological structure. Biophys J 1997; 72: 65-76. https://doi.org/10.1016/S0006-3495(97)78647-8 DOI: https://doi.org/10.1016/S0006-3495(97)78647-8
Lo Nostro P, Ninham BW. Hofmeister phenomena: An update on ion specificity in biology. Chem Rev 2012; 112(4): 2286-322. https://doi.org/10.1021/cr200271j DOI: https://doi.org/10.1021/cr200271j
de Felippe J Jr. Desvending the secrets of cancer. Unstructured water promotes carcinogenesis and structured water restores cellular physiology and bioenergetics by turning cancer cells into normal cells. Hypothesis of carcinogenesis. In Part II- Pathophysiology: desvending the secrets of cancer 2005 (Integrative Medical Oncology – Pathophysiology and treatment). essay, Medicina Intensiva de la Universidade do Rio de Janeiro.
Boskey AL, Blank RD, Doty SB. Vitamin C-sulfate inhibits mineralization in chondrocyte cultures: A caveat. Matrix Biol 2001; 20: 99-106. https://doi.org/10.1016/S0945-053X(01)00116-0 DOI: https://doi.org/10.1016/S0945-053X(01)00116-0
Verlangieri J, Mumma RO. In vivo sulfation of cholesterol by ascorbic acid 2-sulfate. Atherosclerosis 1973; 17: 37-48. https://doi.org/10.1016/0021-9150(73)90133-0 DOI: https://doi.org/10.1016/0021-9150(73)90133-0
Szent-Gyorgy A. The living state – with observations on cancer. New York and London: Academic Press 1972. https://doi.org/10.1016/B978-0-12-680960-2.50012-9 DOI: https://doi.org/10.1016/B978-0-12-680960-2.50012-9
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.