A Case Report on Prolonged Response with Trastuzumab Emtansine (T-DM1) in Recurrent Advance Breast Cancer Setting

Authors

DOI:

https://doi.org/10.30683/1929-2279.2023.12.9

Keywords:

T-DM1, biosimilar, prolonged response, recurrent cancer, breast cancer, HER2-positive

Abstract

Breast cancer holds the dubious distinction of being the most prevalent malignant tumor among women worldwide the 5 year survival rate for patients with advanced or metastatic forms of the disease is estimated at a mere 23%, with approximately 20% of cases exhibiting an amplification of the human epidermal growth factor receptor 2 (HER2). HER2 overexpression was linked to a dismal prognosis prior to the advent of targeted HER2 therapies. The introduction of ado-trastuzumab emtansine (T-DM1) has emerged as one of the standard treatment options for HER2-positive breast cancer patients who experience a recurrence or progression of the disease. This case concerns a patient with recurrent metastatic breast cancer who achieved an unusually extended period of time without the disease progressing while on T-DM1 treatment. After experiencing disease progression on multiple treatment lines involving trastuzumab, the patient achieved a nearly complete clinical remission (cCR) with T-DM1 therapy. The availability of cost-effective biosimilars has expanded access to advanced biologic therapies, which were previously limited to a small segment of the population due to the cost barrier.

References

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Published

2023-12-11

How to Cite

Bedi, P. S., Walia, M., Thummar, V., & Mehta, P. (2023). A Case Report on Prolonged Response with Trastuzumab Emtansine (T-DM1) in Recurrent Advance Breast Cancer Setting. Journal of Cancer Research Updates, 12, 49–53. https://doi.org/10.30683/1929-2279.2023.12.9

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