Inflammation and Cancer: Critical View
DOI:
https://doi.org/10.6000/1927-7229.2018.07.02.4Keywords:
TLR, PAMPs, DAMPs, TNF-α, IL-1β, IL-6, NF-KB, STAT-3, HIF-1α, TGF-β, Tumor associated macrophages, Tumor associated neutrophils.Abstract
Inflammation is the physiological response to an injury, it could be chemical, thermal, physical and infectious for reparative activity to injury. Recent data suggest that chronic inflammation leads to cancer development. Inflammatory mediators released to surrounding environment due to inflammation by inflammatory cells acts as a defensive or offensive depends on secretion of chemical mediators of inflammation such as growth factors, cytokines activating various transcriptional pathways bring about cell proliferation, angiogenesis further leads to tumor growth. This article describe the role of inflammatory cells and its mediators to development of cancer, various underlying unanswered future challenge questions in association with inflammation and cancer.
References
Grivennikov SI, Greten FR, Michael K. Immunity, inflammation and cancer. Cell 2010; 140: 883-99. https://doi.org/10.1016/j.cell.2010.01.025
Shabnam S, Michael K. Immunity, inflammation, and cancer: an eternal fight between good and evil. The Journal of Clinical Investigation 2015; 125: 3347-55. https://doi.org/10.1172/JCI80007
Thiago TM, Ivan CM, Olivier H. The role of mast cells in cancers. F1000 prime Rep 2015; 7: 9.
Shrihari TG. Dual role of inflammatory mediators in cancer. E Cancer Medical Science 2017; 11: 721. https://doi.org/10.3332/ecancer.2017.721
Korniluk A, Koper O, Kemona H, Dymicka-piekarska V. From inflammation to cancer. Ir J Med Sci 2016; 2: 1-6.
Paola A, Germano G, Marchesi F, Mantovani A. Chemokines in cancer related inflammation. Experimental Cell Research 2011; 317: 664-73. https://doi.org/10.1016/j.yexcr.2010.11.013
Colotta F, Allavena P, Sica A, Garlanda C, Mantovani A. Cancer related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 2009; 30: 1073-81. https://doi.org/10.1093/carcin/bgp127
Chai EZP, Siveen KS, Muthu K, Shanmugam, Arfuso F, Gautamsethi. Analysis of the intricate relationship between chronic inflammation and cancer. Biochemical Journal 2015; 1: 1-15. https://doi.org/10.1042/BJ20141337
Katoh H, Watanabe M. Myeloid –derived suppressor cells and therapeutic strategies in cancer. Mediators of Inflammation 2015; 8: 1-12. https://doi.org/10.1155/2015/159269
Noy R, Pollard JW. Tumor associated macrophages: From mechanisms to therapy. Immunity 2014; 41: 49-61. https://doi.org/10.1016/j.immuni.2014.06.010
Candido J. Cancer-related inflammation. Journal of Clinical Immunology 2013; 33: 579-84. https://doi.org/10.1007/s10875-012-9847-0
Oian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010; 141: 39-51. https://doi.org/10.1016/j.cell.2010.03.014
Katoh H, Watanabe M. Myeloid –derived suppressor cells and therapeutic strategies in cancer. Mediators of Inflammation 2015; 8: 1-12. https://doi.org/10.1155/2015/159269
Chai EZ, Siveen KS, Shanmugam MK, Arfuso F, Sethi G. Analysis of the intricate relationship between chronic inflammation and cancer. Biochemical Journal 2015; 468: 1-15. https://doi.org/10.1042/BJ20141337
Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature 2008; 454: 436-44. https://doi.org/10.1038/nature07205
Okada F. Inflammation related carcinogenesis: current findings epidemiological trends. Yonago Acta Medica 2014; 57: 65-72.
Ohnishi S, Ma N, Thanam R, Pinlaor S, Hammam O, Murata M, Kawanishi S. DNA damage in inflammation related carcinogenesis and cancer stem cells. Oxidative Medicine and Cellular Longevity 2013; 43: 1-9. https://doi.org/10.1155/2013/387014
Diakos CI, Charles CA, Mcmillan DC, Clarke SJ. Cancer related inflammation and treatment effectives. The Lancet Oncology 2014; 15: 493-503. https://doi.org/10.1016/S1470-2045(14)70263-3
Balkwill FR, Mantovani A. Cancer related inflammation: common themes and therapeutic opportunities. Seminars in Cancer Biology 2012; 22: 33-40. https://doi.org/10.1016/j.semcancer.2011.12.005
Glauben L, Marjorie De La Fuente PT, Chanitra T, Marcela AH. Chronic inflammation and cytokines in the tumor microenvironment. Journal of Immunology Research 2014; 3: 1-19.
Douglas M, Gabrilovich DI. Myeloid – derived suppressor cells in tumor microenvironment: Expect the unexpected. Journal of Clin Invest 2015; 125: 3356-64. https://doi.org/10.1172/JCI80005
Condamine T, Gabrilovich DI. Can the suppressive activity of myeloid –derived suppressor cells be “chop”ped. Immunity 2014; 41(3): 341-342. https://doi.org/10.1016/j.immuni.2014.08.016
Shrihari TG. Inflammation related cancer- Highlights. J Carcinog Mutagen 2016; 7: 269.
Chen L, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun 2014; 5: 5241. https://doi.org/10.1038/ncomms6241
Blankenstein T, Coulie PG, Gilboa E, Jaffee EM. The determinants of tumour immunogenicity. Nat Rev Cancer 2012; 12(4): 307-313. https://doi.org/10.1038/nrc3246
Spranger S, et al. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med 2013; 5(200): 200ra116. https://doi.org/10.1126/scitranslmed.3006504
Kitamura T, Qian BZ, Pollard JW. Immune cell promotion of metastasis. Nat Rev Immunol 2015; 15(2): 73-86. https://doi.org/10.1038/nri3789
Sethi G, Shanmugam MK, Ramachandran L, Kumar AP, Tegaonkar V. Multifaceted link between cancer and inflammation. Biosci Rep 2012; 32(1): 1-15. https://doi.org/10.1042/BSR20100136
Shrihari TG. Inflammation –related cancer or cancer-related inflammation. The European Research Journal 2017; 2: 1-5. (Early online).
Downloads
Published
Issue
Section
How to Cite
Similar Articles
- T.G. Shrihari, Chronic Inflammatory Mediators Induced Malignant Changes in Tumor Microenvironment of Oral Squamous Cell Carcinoma-New Insight , Journal of Analytical Oncology: Vol. 7 No. 4 (2018)
- T.G. Shrihari, Chronic Inflammatory Mediators Induced Malignant Changes in Inflammatory Microenvironment of Oral Potentialy Malignant Conditions - An Emerging Concept , Journal of Analytical Oncology: Vol. 7 No. 4 (2018)
- Archana Venkatesan, Karthick Sivanatham, Immune Evasion and Resistance in Cancer Progression: Overcoming Checkpoint Inhibition Challenges with Personalized Immunotherapy Guided by PD-L1 Expression , Journal of Analytical Oncology: Vol. 14 (2025)
- Mariella Caffo, Gerardo Caruso, Valeria Barresi, Maria Angela Pino, Mario Venza, Concetta Alafaci, Francesco Tomasello, Immunohistochemical Study of CD68 and CR3/43 in Astrocytic Gliomas , Journal of Analytical Oncology: Vol. 1 No. 1 (2012)
- Agnaldo L. Silva-Filho, Andrezza V. Belo, Elisa Lopes Lages, Rívia Mara Lamaita, Márcia Mendonça Carneiro, Sílvia P. Andrade, Distinct Pattern of Inflammatory Enzyme Activities in Human Ovarian Cancer and Benign Myoma , Journal of Analytical Oncology: Vol. 1 No. 1 (2012)
- Arun Chairmadurai, Harish Chandra Goel, Sandeep Jain, Aklank Jain, Hridayesh Prakash, Ra-SBRT is Potential Immune Adjuvant for Innate Immune Cell Populations in Advance Stage NSCLC Patients , Journal of Analytical Oncology: Vol. 8 (2019)
- Xin Liu, Yan Chen, Zhi Ping Wu, Cong Guo Jin, Xiao Qun Chen, Jia Li, Yong Chun Zhou, Xi Cai Wang, A DNA Vaccine Targeting the Fetal Liver Kinase-1 (Flk-1) can Activate the Special CD8+ T Cell and Inhibit the Metastasis of Orthotopic Lewis Lung Cancer Model , Journal of Analytical Oncology: Vol. 2 No. 4 (2013)
- Mariana Varna, Philippe Bertheau , Luc G. Legrès , Tumor Microenvironment in Human Tumor Xenografted Mouse Models , Journal of Analytical Oncology: Vol. 3 No. 3 (2014)
- Arturo Novoa Vargas, Karla Sánchez Bautista, Ismael Coudillo Luna, Lipoidic Cells Ovary Cancer, Clinic Case and Literature Review , Journal of Analytical Oncology: Vol. 3 No. 1 (2014)
- Jason S. Hamilton, Guido F. Verbeck, One-Cell Analysis as a Technique for True Single-Cell Analysis of Organelles in Breast Tumor and Adjacent Normal Tissue to Profile Fatty Acid Composition of Triglyceride Species , Journal of Analytical Oncology: Vol. 5 No. 2 (2016)
You may also start an advanced similarity search for this article.
Most read articles by the same author(s)
- T.G. Shrihari, Chronic Inflammatory Mediators Induced Malignant Changes in Inflammatory Microenvironment of Oral Potentialy Malignant Conditions - An Emerging Concept , Journal of Analytical Oncology: Vol. 7 No. 4 (2018)
- T.G. Shrihari, Myeloid Derived Suppressor Cells in Oral Cancer: An Emerging Concept , Journal of Analytical Oncology: Vol. 7 No. 2 (2018)
- T.G. Shrihari , Endorphins - A Novel Holistic Therapeutic Approach to Cancer , Journal of Analytical Oncology: Vol. 7 No. 3 (2018)
- T.G. Shrihari, Chronic Inflammatory Mediators Induced Malignant Changes in Tumor Microenvironment of Oral Squamous Cell Carcinoma-New Insight , Journal of Analytical Oncology: Vol. 7 No. 4 (2018)