Nanoradiopharmaceuticals: Development oF Labeling Process for Polymeric Nanoparticles

• Augusto Bordim

  Laboratory of Nanoradiopharmaceuticals- Rio de Janeiro- Brazil

• Beatriz Ferreira de Carvalho Patricio

  Laboratory of Nanoradiopharmaceuticals- Rio de Janeiro- Brazil

• Michelle Álvares Sarcinelli

  Laboratory of Nanoradiopharmaceuticals- Rio de Janeiro- Brazil

• Marta de Souza Albernaz

  Laboratory of Nanoradiopharmaceuticals- Rio de Janeiro- Brazil

• Ralph Santos-Oliveira

  Laboratory of Nanoradiopharmaceuticals- Rio de Janeiro- Brazil

 Nanomedicine, probably, is the future of modern medicine. Hence, there is a global effort being made in the development of nanopharmaceuticals. Among all the nano-pharmaceuticals developed so far, radiopharmaceuticals are the fewest in number of published studies. The development of nanoradiopharmaceuticals is complex but not impossible. In this work we discuss the possibility and the results of developing 4 nanoradiopharmaceuticals based on 3 different types of nanoparticles as alternative drug delivery systems. Also we present the preliminary results in animals.

Wang T, Petrenko VA, Torchilin VP. Paclitaxel-loaded polymeric micelles modified with mcf-37 cell specific phage protein:enhaced binding to target cancer cells and increased cytotoxicity. Mol Pharmaceutics 2010; 7(4):1007-14.

Al-Jamal W, Al-Jamal K, Bomans P, Frederik P, Kostarelos K. Functionalized-quantum-dot-liposome hybrids as multimodal nanoparticles for cancer. Small 2008; 4(9): 1406-15. http://dx.doi.org/10.1002/smll.200701043

Phillips WT, Goins BA, Bao A Radioactive liposomes. Rev Nanomed Nanobio 2009; 1(1): 69-83.

Hamoudeh M, Kamleh MA, Diab R, Fessi H. Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer. Adv Drug Deliv Rev 2008; 60(12):1329-46. http://dx.doi.org/10.1016/j.addr.2008.04.013

Patrcio BFC, Weissmuller G, Santos-Oliveira R. Develop- ment of the 153-Sm-EDTMP nanoradiopharmaceuticals. J Label Compd Radiopharma 2011; 54: S1-S576.

Sa LTM, Albernaz MS, Patricio BFC, Junior MVF, Coelho BF, Bordim A, et al. Biodistribution of nanoparticles: initial considerations. J Pharm Biomed Anal 2012; 70: 602-4. http://dx.doi.org/10.1016/j.jpba.2012.06.008

Patrcio BFC, Bordim A, Albernaz MS, Guimaraes TT, Santos-Oliveira R. Influence of radiation on polymeric nanoparticles and in labeling process with 99mTc. Adv Sci Eng Med 2012; 4(3): 271-272(2).

• PDF