Logo

Nitric Oxide Metabolites Change in Cisplatin-Induced Nephrotoxicity: The Effect of L-Arginine and Losartan

Authors

  • Zahra Pezeshki

    Water & Electrolytes Research Center

  • Mehdi Nematbakhsh

    Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran

DOI:

https://doi.org/10.6000/1927-7229.2013.02.02.9

Keywords:

Cisplatin, Nitric oxide, L-arginine, Losartan, Nephrotoxicity.

Abstract

 Cisplatin (CP) is an anticancer drug with the most common side effect of nephrotoxicity. CP also alters the level of nitric oxide (NO), and NO itself may promote CP-induced nephrotoxicity.

In this short report, we measured the serum levels of NO metabolites in an animal model of CP-induced nephrotoxicity, and tested the effect of two nephroprotectant agents; l-arginine and losartan on serum levels of NO metabolites.

The results indicated that CP increased the serum concentration of nitrite but not nitrate. However, l-arginine and losartan significantly decreased the serum level of nitrite.

It seems that l-arginine and losartan provide their nephroprotectant effect against CP-induced nephrotoxicity by reducing the serum level of nitrite.

References

Saleh S, El-Demerdash E. Protective effects of L-arginine against cisplatin-induced renal oxidative stress and toxicity: role of nitric oxide. Basic Clin Pharmacol Toxicol 2005; 97: 91-7. http://dx.doi.org/10.1111/j.1742-7843.2005.pto_114.x

Saleh S, Ain-Shoka AA, El-Demerdash E, Khalef MM. Protective effects of the angiotensin II receptor blocker losartan on cisplatin-induced kidney injury. Chemotherapy 2009; 55: 399-406. http://dx.doi.org/10.1159/000262453

Eshraghi-Jazi F, Nematbakhsh M, Nasri H, Talebi A, Haghighi M, Pezeshki Z, et al. The protective role of endogenous nitric oxide donor (L-arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model. J Res Med Sci 2011; 16(11): 1389-96.

Haghighi M, Nematbakhsh M, Talebi A, Nasri H, Ashrafi F, Roshanaei K, et al. The role of angiotensin II receptor 1 (AT1) blockade in cisplatin-induced nephrotoxicity in rats: gender-related differences. Ren Fail 2012; 34(8): 1046-51. http://dx.doi.org/10.3109/0886022X.2012.700886

Ekor M, Emerole GO, Farombi EO. Phenolic extract of soybean (Glycine max) attenuates cisplatin-induced nephrotoxicity in rats. Food Chem Toxicol 2010; 48: 1005-12. http://dx.doi.org/10.1016/j.fct.2009.12.027

Saad SY, Najjar TA, Daba MH, Al-Rikabi AC. Inhibition of nitric oxide synthase aggravates cisplatin-induced nephrotoxicity: effect of 2-amino-4-methylpyridine. Chemotherapy 2002; 48: 309-15. http://dx.doi.org/10.1159/000069714

Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric oxide 2001; 5: 62-71.

Kone BC, Baylis C. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney. Am J Physiol 1997; 272: F561-78.

Gordge M. How cytotoxic is nitric oxide? Exper Nephrol 1998; 61: 12-6. http://dx.doi.org/10.1159/000020499

Goligorsky MS, Brodsky SV, Noiri E. Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int 2002; 61: 855-61. http://dx.doi.org/10.1046/j.1523-1755.2002.00233.x

Kone BC. Nitric oxide in renal health and disease. Am J Kidney Dis 1997; 30: 311-33. http://dx.doi.org/10.1016/S0272-6386(97)90275-4

Chirino YI, Trujillo J, Sanchez-Gonzalez DJ, Martinez-Martinez CM, Cruz C, Bobadilla NA, et al. Selective iNOS inhibition reduces renal damage induced by cisplatin. Toxicol Lett 2008; 176: 48-57. http://dx.doi.org/10.1016/j.toxlet.2007.10.006

Downloads

Published

2013-04-03

Issue

Vol. 2 No. 2 (2013)

Section

Articles

How to Cite

Nitric Oxide Metabolites Change in Cisplatin-Induced Nephrotoxicity: The Effect of L-Arginine and Losartan . (2013). Journal of Analytical Oncology, 2(2),  117-119. https://doi.org/10.6000/1927-7229.2013.02.02.9

Similar Articles

1-10 of 12

You may also start an advanced similarity search for this article.