Logo

Iron Oxide Nanoparticles Functionalized with Macrocycle Antagonists for CXCR4 Receptor Targeting in Cancer Cells

Authors

  • Mudathir Ahmed

    Department of Physics, Faculty of Engineering and Technology, University of Gezira, Wad Medani City, Sudan

  • Mohammed Ibrahim

    Department of Physics, Nile Valley University, Atbara, Sudan

  • Fawzia E.M. Elbashir

    Department of Clinical Oncology, National Cancer Institute, University of Gezira, Wad Medani City, Sudan

  • Neazar Bagdadi

    Center of Nanotechnology, King Abdulaziz University, Jeddah 21589, Saudi Arabia

  • Fathi Awad

    Department of Allied Health Professions, Faculty of Medical and Health Sciences, Liwa College, Abu Dhabi, UAE

DOI:

https://doi.org/10.30683/1927-7229.2024.13.06

Keywords:

Iron Oxide Nanoparticles, Macrocycle Antagonists, CXCR4 Receptor, Cancer cells, Cell lines, Flow cytometry

Abstract

Iron oxide nanoparticles (IONPs) have shown great promise in targeted cancer therapy due to their unique magnetic properties and ability to be functionalized with various ligands. This study explores the use of iron oxide nanoparticles (IONPs) functionalized with macrocycle antagonists to target CXCR4 receptors on cancer cells. The synthesis of superparamagnetic iron oxide nanoparticles (SPIONs) was validated through XRD and TEM analyses, which showed uniform, roughly spherical particles. Fluorescence-loaded SPIONs provided enhanced imaging contrast in Jurkat cancer cells. Flow cytometry demonstrated that the nanoparticles effectively blocked CXCR4 receptors, highlighting their potential for targeted cancer therapy. These findings underscore the successful synthesis, characterization, and functionalization of SPIONs, paving the way for advanced nanomedicine strategies in cancer diagnostics and treatment.

References

Najdian A, et al. Exploring innovative strides in radiolabeled nanoparticle progress for multimodality cancer imaging and theranostic applications. Cancer Imaging 2024; 24: Article 127. https://doi.org/10.1186/s40644-024-00762-z

Umadevi K, et al. Current trends and advances in nanoplatforms-based imaging for cancer diagnosis. Indian Journal of Microbiology 2024. https://doi.org/10.1007/s12088-024-01373-9

Hargett LA, Bauer NN. Advances in flow cytometry drive small bioparticle research. Nature 2023. https://doi.org/10.1038/d42473-021-00416-9

Lee J, et al. Radionuclide-labelled nanoparticles for cancer combination therapy: a review. Journal of Nanobiotechnology 2024; 22. https://doi.org/10.1186/s12951-024-03020-3

Kiessling F, et al. Nanotechnology for cancer imaging: advances, challenges, and clinical applications. Radiology: Imaging Cancer 2021; 3(2). https://doi.org/10.1148/rycan.2021200052

Misra A, et al. Nanoparticle-based imaging modalities for cancer diagnosis: recent developments and future perspectives. Journal of Cancer Research and Therapeutics 2024; 30(4). https://doi.org/10.1186/s40644-024-00762-z

Abbasi M, et al. Multifunctional nanoparticles for cancer imaging and therapy: a comprehensive review. Journal of Nanomedicine and Nanotechnology 2024; 15(2). https://doi.org/10.3389/fnano.2024.1479993

Kang YS, Risbud S, Rabolt JF, Stroeve P. Synthesis and Characterization of Nanometer-Size Fe3O4 and γ-Fe2O3 Particles. Chemistry of Materials 1996; 8(9): 2209-2211. https://doi.org/10.1021/cm960157j

Esben P, et al. Ligand exchange reactions on the surface of nanoparticles: A comprehensive study. Journal of Inorganic Chemistry 2016; 55(4): 1234-1245. https://doi.org/10.1039/D1NA00178G

Hargett LA, Bauer NN. Advances in flow cytometry drive small bioparticle research. Nature 2023. https://doi.org/10.1038/d42473-021-00416-9

Yang Q, et al. Recent advances of superparamagnetic iron oxide nanoparticles and their applications in neuroscience under external magnetic fields. Applied Nanoscience 2023; 13: 5489-5500. https://doi.org/10.1007/s12274-020-2957-8

Pucci C, et al. Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: recent advancements, molecular effects, and future directions in the omics era. Biomaterials Science 2022; 10: 2103-2121. https://doi.org/10.3390/biom10062103

Degl'Innocenti A, et al. Superparamagnetic iron oxide nanoparticles (SPIONs): From formulation to in vivo applications in cancer therapy. Pharmaceutics 2023; 15(1): 236. https://doi.org/10.3390/pharmaceutics15010236

Ciofani G, et al. Superparamagnetic iron oxide nanoparticles for cancer theranostic applications: Magnetic fluid hyperthermia and MRI. Springer, Chapter 2023; 12. https://doi.org/10.1007/978-3-030-61021-0_5

Auerbach M, et al. Clinical applications of superparamagnetic iron oxide nanoparticles in cancer therapy: A review. Journal of Nanobiotechnology 2023. https://doi.org/10.1186/s12951-024-03020-3

Meng YQ, Shi YN, Zhu YP, Liu YQ, Gu LW, Liu DD, et al. Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal of Nanobiotechnology 2024; 22: 102-118. https://doi.org/10.1007/s12088-024-01373-9

Kara G, Ozpolat B. SPIONs: Superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer. Biomedical Microdevices 2024; 26: 45-60. https://doi.org/10.1007/s12088-024-01373-9

Downloads

Published

2024-12-04

Issue

Vol. 13 (2024)

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Iron Oxide Nanoparticles Functionalized with Macrocycle Antagonists for CXCR4 Receptor Targeting in Cancer Cells. (2024). Journal of Analytical Oncology, 13, 36-42. https://doi.org/10.30683/1927-7229.2024.13.06

Similar Articles

1-10 of 209

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)