Successful Treatment, with Chemotherapy and Intravenous Administration of Ascorbic Acid, of a Patient with Peripheral T-Cell Lymphoma, Not Otherwise Specified

• Chiaki Tokoro

  Palliative Care Team, Shinseikai Daiichi Hospital, Nagoya, Japan

  https://orcid.org/0009-0007-3277-1968

• Atsushi Tashiro

  Palliative Care Team, Shinseikai Daiichi Hospital, Nagoya, Japan

• Kenji Ina

  Palliative Care Team, Shinseikai Daiichi Hospital, Nagoya, Japan and Department of Geriatric Medicine, Shinseikai Daiichi Hospital, Nagoya, Japan

  https://orcid.org/0000-0001-8646-0611

• Yoshiteru Tanaka

  Department of Pharmacy, Shinseikai Daiichi Hospital, Nagoya, Japan

• Hiroyuki Kobayakawa

  Kobayakawa Clinic, Nagoya, Japan

• Takashi Yoshida

  Department of Clinical Oncology, Nagoya Memorial Hospital, Nagoya, Japan

  https://orcid.org/0000-0002-1516-9613

• Satoshi Kayukawa

  Department of Clinical Oncology, Nagoya Memorial Hospital, Nagoya, Japan

  https://orcid.org/0000-0002-9646-5114

Here, we report the case of a 64-year-old man with peripheral T-cell lymphoma, not otherwise specified, who complained of diffuse lymphadenopathy and pancytopenia. This patient received the CHOP regimen followed by the CHP plus brentuximab vedotin regimen, and eventually experienced severe adverse effects, such as leukocytopenia and thrombocytopenia. He was then intravenously administered high doses of ascorbic acid to enhance the effects of chemotherapy drugs and reduce the intensity of the side effects. Positron emission tomography-computed tomography revealed a complete response of the lesions to combination therapy. This case report demonstrated the feasibility, efficacy, and acceptable toxicity of high-dose ascorbic acid in patients undergoing chemotherapy.

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